Unnecessary test ordering in clinical trials: human chorionic gonadotropin as an example
نویسندگان
چکیده
منابع مشابه
A test of maternal human chorionic gonadotropin during pregnancy as an adaptive filter of human gestations.
The risk of abnormalities and morbidity among live births increases with advanced maternal age. Explanations for this elevated morbidity invoke several maternal mechanisms. The relaxed filter stringency (RFS) hypothesis asserts that mothers, nearing the end of their reproductive lifespan, reduce the stringency of a screen of offspring quality in utero based on life-history traits of parity and ...
متن کاملHuman chorionic gonadotropin as a tumor marker.
Ectopic production and secretion of hormones by a wide variety of tumors has been known for decades. Initially, ectopic hormone secretion was recognized by signs and symptoms of excess circulating biologically active hormone. With development of more sophisticated assay techniques, biologically inactive fragments and "big" forms of authentic hormones have been identified in these syndromes. Rec...
متن کاملBetween-method variation in human chorionic gonadotropin test results.
BACKGROUND Results on sera and calibrators vary 1.4- to 2.3-fold among commercial human chorionic gonadotropin (hCG) assays. The relative contributions of calibrators, standards, hCG charge isoforms, and major structural variants to this variation have not been quantified. METHODS Purified hCG was separated by isoelectric focusing into four fractions with pI ranges of 3-4, 4-5, 5-6, and 6-7. ...
متن کاملHuman Chorionic Gonadotropin
A highly active preparation of human chorionic gonadotropin has been obtained by simple methods of column chromatography on diethylaminoethyl Sephadex and Sephadex G-100. The preparation appeared homogeneous by disc and immunoelectrophoresis, ultracentrifugation, and end group analysis. It assayed at 12,000 i.u. per mg by the rat prostrate gland and accessory sex organ method. The ~20,~ value w...
متن کاملFabrication of an Electrochemical Immunosensor for Determination of Human Chorionic Gonadotropin Based on PtNPs/Cysteamine/AgNPs as an Efficient Interface
An ultrasensitive electrochemical immunosensor for the detection of tumor marker human chorionic gonadotropin (hCG) was developed with a limit of detection as low as 2 pg mL-1 in phosphate buffer. The Platinum nanoparticles (PtNPs) were electrodeposited to modify the gold surface and to increase enlarging the electrochemically active sites, resulting in the facilitation of electron exchange. Cy...
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ژورنال
عنوان ژورنال: Advances in Laboratory Medicine / Avances en Medicina de Laboratorio
سال: 2020
ISSN: 2628-491X
DOI: 10.1515/almed-2019-0004